The oxycodone in OXYCONTIN might lead to spasm in the sphincter of Oddi. Opioids may induce increases in the serum amylase. Regularly Assess patients with biliary tract disease, including acute pancreatitis, for worsening indicators.If the decision is built to prescribe a benzodiazepine or other CNS depressant concomitantly with an opioid analgesic